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同时发生两种原因的危重溶血性贫血十分罕见,现将本院收治1例报告如下。 患者,女,29岁,1986年12月因感冒服用速效感冒胶囊及扑热息痛,3天后下肢出现散在出血点、发热、齿龈出血、月经增多,经骨穿确诊为急性再生障碍性贫血,应用ALG治疗2疗程,肌注丙酸睾丸酮,口服强的松。1987年5月血象好转(Hb 80g/L,WBC 4.0×10~9/L,BPC 100×10~9/L)而出院。1986年曾怀孕2个月,因患有再障作人工流产。1990年5月第2次妊娠,起初无任何不适;1991年2月因尿路感染,用抗菌素无效,继后高热,腰背酸痛,尿色呈褐黄色,乏力,心悸。血常规:Hb 72g/L、WBC 3.35×10~9/L、BPC 70×10~9/L、网织红细胞4%,涂片见有核红细胞。体检示巩膜黄染,心肺(一),腹软,孕7月,胎心正常,肝脏未及,脾脏肋下触及。诊断:“溶血性贫血,原因待查。孕7月”转来我院住院。以往曾输血,未出现输血反应。
The simultaneous occurrence of two causes of severe hemolytic anemia is very rare, now admitted to a hospital in 1 case as follows. Patients, female, 29 years old, December 1986 Rapid cold capsules and paracetamol for cold, after 3 days, scattered bleeding, lower extremity bleeding, bleeding gums, increased menstrual flow, diagnosed as acute aplastic anemia by the bone wear, the application of ALG treatment 2 courses, intramuscular injection of testosterone propionate, oral prednisone. In May 1987 the blood was recovered (Hb 80g / L, WBC 4.0 × 10 ~ 9 / L, BPC 100 × 10 ~ 9 / L) and discharged. 1986 was 2 months pregnant, suffering from aplastic anemia due to artificial abortion. May 1990, the second pregnancy, at first without any discomfort; February 1991 due to urinary tract infection, with antibiotics, followed by fever, back pain, urine color was brown, fatigue, palpitations. Blood: Hb 72g / L, WBC 3.35 × 10 ~ 9 / L, BPC 70 × 10 ~ 9 / L, reticulocyte 4% smear see the nucleated red blood cells. Physical examination showed scleral yellow dye, cardiopulmonary (a), abdominal soft, pregnancy in July, normal fetal heart rate, liver and spleen ribs touch. Diagnosis: “Hemolytic anemia, causes to be checked. Pregnancy July” transferred to our hospital. Transfusion in the past, no transfusion reaction.