目的:探讨高纯尿促性素(HP-h MG)对卵巢储备功能正常患者体外受精-胚胎移植(IVFET)促排卵治疗的效果。方法:回顾性分析本中心卵巢储备功能正常且首次进入周期、进行黄体期Gn RH激动剂长方案助孕治疗患者的临床资料,其中使用HP-h MG促排卵者(HP-h MG组)57例,使用重组卵泡刺激素(r FSH组)140例,比较其促性腺激素(Gn)用量、刺激天数、获卵数、种植率、临床妊娠率、h CG注射日雌、孕激素水平以及因卵巢过度刺激综合征(OHSS)风险周期取消率等。结果:HP-h MG组年龄明显高于r FSH组(29.4±3.2岁vs 28.3±3.0岁,P=0.026),其他基础情况组间相似。HP-h MG组Gn总量和刺激天数高于r FSH组,h CG注射日雌、孕激素水平均低于r FSH组,获卵数低于r FSH组,但可用胚胎率高于r FSH组,因OHSS风险而取消周期率低于r FSH组,差异均有统计学意义(P<0.05)。HP-h MG组和r FSH组妊娠率分别为65.3%和61.7%,但无统计学差异。结论:相比r FSH促排卵,HP-h MG作用温和,获卵数少,但可用胚胎率高,发生OHSS风险小,临床妊娠率有增高趋势。 Objective: To investigate the effect of HP-h MG on ovulation induction in vitro fertilization-embryo transfer (IVFET) patients with normal ovarian reserve. Methods: We retrospectively analyzed the clinical data of patients with ovarian reserve functionally normalized and entering the cycle for the first time. The clinical data of patients with long-term luteinizing Gn-RH agonist therapy were obtained. Among them, HP-h MG ovulation (HP-h MG) Cases, the use of recombinant FSH (r FSH group) 140 cases, compared the amount of gonadotropin (Gn), the number of stimulation days, the number of oocytes, implantation rate, clinical pregnancy rate, h CG injection of estrogen and progesterone levels and Ovarian hyperstimulation syndrome (OHSS) risk cycle cancellation rate and so on. Results: The age of HP-h MG group was significantly higher than that of r FSH group (29.4 ± 3.2 years vs 28.3 ± 3.0 years, P = 0.026). Other basic conditions were similar between groups. The total amount of Gn and stimulation days in HP-h MG group were higher than those in r FSH group. The levels of estrogen and progesterone in h CG injection day were lower than those in r FSH group and the number of oocytes retrieved was lower than that in r FSH group. However, the available embryo rate was higher than r FSH Group, due to OHSS risk cancel cycle rate lower than r FSH group, the difference was statistically significant (P <0.05). The pregnancy rates in HP-h MG group and r FSH group were 65.3% and 61.7% respectively, but there was no significant difference. CONCLUSIONS: HP-h MG has a modest effect on ovulation induction compared with r FSH. However, the number of oocytes retrieved is small, but the available embryo rate is high, the risk of OHSS is low, and the clinical pregnancy rate tends to increase.