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目的:研究上皮-间充质转变调控基因Slug在卵巢浆液性乳头状腺癌组织中的表达及其临床预后意义。方法:采用免疫组织化学(EnVisionTM)法分别检测80例卵巢浆液性乳头状腺癌组织及其癌旁组织中Slug的表达,并运用Kaplan-Meier法分析Slug的表达对患者预后的影响。结果:上皮-间充质转变调控基因Slug在卵巢浆液性乳头状腺癌组织及癌旁组织中的阳性表达率分别为52.50%、13.75%,两者之间差异有统计学意义(χ2=27.11,P<0.01);上皮-间充质转变调控基因Slug的表达与TNM分期、淋巴结转移、远处脏器转移、雌激素阳性表达有关(P<0.05),但与患者年龄、肿瘤直径、组织学分化无关(P>0.05);卵巢浆液性乳头状腺癌组织上皮-间充质转变调控基因Slug表达阴性的患者生存率明显高于阳性患者(χ2=4.09,P<0.05)。结论:卵巢浆液性乳头状腺癌组织中上皮-间充质转变调控基因Slug过表达可能有利于癌组织的转移,也预示患者预后不良。
Objective: To investigate the expression of epithelial-mesenchymal transition regulatory Slug in ovarian serous papillary adenocarcinoma and its clinical significance. Methods: EnVisionTM was used to detect the expression of Slug in 80 cases of ovarian serous papillary adenocarcinoma tissues and its adjacent tissues. Kaplan-Meier method was used to analyze the influence of Slug expression on the prognosis of patients. Results: The positive expression rates of epithelial-mesenchymal transition regulatory Slug in ovarian serous papillary adenocarcinoma tissues and paracancerous tissues were 52.50% and 13.75%, respectively, with significant difference (χ2 = 27.11 , P <0.01). The expression of epithelial-mesenchymal transition regulatory gene Slug was correlated with TNM staging, lymph node metastasis, distant organ metastasis and estrogen positive expression (P <0.05), but not with age, tumor diameter, (P> 0.05). The survival rate of Slug-negative patients with ovarian serous papillary adenocarcinoma was significantly higher than that of positive patients (χ2 = 4.09, P <0.05). Conclusion: Slug overexpression of epithelial-mesenchymal transition regulator gene in ovarian serous papillary adenocarcinoma may be beneficial to the metastasis of cancerous tissues and also indicate the poor prognosis of patients.