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目的：观察和比较地氟烷和异氟烷对风心病患者循环功能的影响。方法：２０例风湿性病心脏瓣膜置换患者随机均分成两组，每例在麻醉诱导前局麻下作桡动脉穿刺和右颈内静脉穿刺放置漂浮导管各测循环功能指标、用咪达唑仑 ０， １５ ｍｇ／ｋｇ、芬太尼１０ μｇ／ｋｇ、维库溴铵８ ｍｇ静脉注射麻醉诱导，其后两组分别吸入１．０ ＭＡＣ地氟烷和１．０ ＭＡＣ异氟烷，利用ＨＰ多功能监护仪观察两组在吸入地氟烷或异氟烷前后循环功能的改变。结论：两组在吸入 １． ０ ＭＡＣ地氟烷或 １． ０ ＭＡＣ异氟烷后体循环压力（ＡＢＰ）、体血管阻力（ＳＶＲ）、左心功指数（ＬＶＷＩ）均显著性降低，两组之间这３项功能指标降低幅度没有显著性差异。结论：低浓度地氟烷可以象异氟烷那样安全地应用于风心病患者心脏瓣膜置换手术麻醉。
Objective: To observe and compare the effects of desflurane and isoflurane on circulatory function in patients with rheumatic heart disease. Methods: Twenty patients with rheumatic heart disease were randomly divided into two groups. Each patient underwent radial artery puncture and catheterization of the right internal jugular vein before anesthesia induction, , 15 mg / kg, fentanyl 10 μg / kg, vecuronium 8 mg intravenous anesthesia induction, followed by two groups were inhaled 1.0 MAC desflurane and 1.0 MAC isoflurane, with more HP Functional monitors were observed in both groups before inhaling desflurane or isoflurane cycle function changes. Conclusion: Both groups inhaled 1. 0 MAC desflurane or 1. After 0 MAC, the ABP, SVR and LVWI decreased significantly. There was no significant difference between the two groups in the reduction of the three functional indexes. CONCLUSIONS: Low concentrations of desflurane can safely be applied to heart valve replacement surgery in patients with rheumatic heart disease as isoflurane.