研究表明一些天然黄酮类化合物(如金丝桃苷、异槲皮素、槲皮素等)具有抗抑郁作用。夹竹桃科植物罗布麻(Apocynum venetum)中含有大量黄酮类化合物。本次研究了罗布麻叶提取物在大鼠强迫游泳试验(FST)中表现的抗抑郁作用。 材料和方法:罗布麻叶(100g)于70％乙醇中回流提取2次,每次1h,合并乙醇提取液,蒸干后溶于热水,用硫酸调节pH至3.0,过滤,滤液上Diaion HP-20柱,依 Studies have shown that some natural flavonoids (such as hyperin, isoquercetin, quercetin, etc.) have antidepressant effects. The Apocynum venetum contains a large amount of flavonoids. This study investigated the antidepressant effects of extracts of A. venetum leaf extract in a forced swimming test (FST) in rats. Materials and Methods: Apocynum venetum leaf (100g) was extracted and refluxed twice in 70% ethanol for 1 hour. The ethanol extracts were combined, evaporated to dryness, dissolved in hot water, adjusted to pH 3.0 with sulfuric acid, filtered, and filtrated on Diaion HP. -20 columns, according to