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用敏感的免疫测定法检查显示,在急性乙型肝炎中总是存在 IgM 抗-HBc 的反应性,但在无症状的 HBsAg 携带者中通常缺乏或仅能检测到低的滴度。纵向研究证实,在HBV 初次感染的早期阶段,IgM 抗-HBc 升高;数月后不管循环的 HBsAg 是否持续,它仍然下降。由于与近期 HBV 感染短暂相关,IgM 抗体的检测可能有助于鉴别真正的乙型肝炎和以往未被发现的 HBsAg 携带者的非乙型肝炎,后者中的许多急性肝病患者,可能根据在血清中发现 HBsAg 而被误诊为乙型肝炎。
Examination with a sensitive immunoassay revealed that there is always the reactivity of IgM anti-HBc in acute hepatitis B, but usually low or only low titers are detectable in asymptomatic HBsAg carriers. Longitudinal studies confirm that IgM anti-HBc is elevated in the early stages of primary HBV infection; it continues to decline no matter if the circulating HBsAg persists months later. Due to the transient association with recent HBV infection, the detection of IgM antibodies may help identify non-Hepatitis B infections in real hepatitis B and previously undiscovered HBsAg carriers, many of whom may be based on serum levels in serum HBsAg was found to be misdiagnosed as hepatitis B.