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目的：分析偏头痛患者皮肤异常性痛觉（CA）现象及其危险因素，观察普瑞巴林对CA的治疗效果。方法选择符合偏头痛诊断标准的63例患者，根据异常性痛觉症状自评量表（ASC量表）分为CA组（41例）和非CA组（22例），记录患者的CA类型、严重程度及头痛情况，分析CA发生的危险因素。CA组普瑞巴林（150～300mg/d）治疗12周，治疗后1个月和3个月记录头痛和CA的变化，分析普瑞巴林对CA的干预效果。结果65．1％偏头痛患者存在CA，其中温度相关性、静态及动态机械性CA分别占85．4％、29．4％和22．0％。女性、病程长及药物过度使用者易出现CA。与基线相比，普瑞巴林治疗1个月和3个月后，ASC量表评分和CA人数均明显下降（P＜0．05），头痛程度、MIDAS和HIT-6量表评分均显著下降（P＜0．05）。药物治疗总有效率85．4％。结论65．1％的偏头痛患者存在CA，CA的发生与患者性别、病程及药物过度使用有密切关系。普瑞巴林治疗偏头痛患者中枢敏感化可能有效。“,”Objective To observe the predictors of cutaneous allodynia( CA) in migraine patients and the effects of pre-gabalin in alleviating CA.Methods Sixty-three patients with migraine were included and divided into two groups,CA group(41 patients)and non-CA group(22 patients),according to Allodynia Symptom Checklist(ASC).The presence of CA, its type and severity, and details of headache were enquired and the predictors of CA were analyzed.Forty-one patients with CA were treated with pregabalin (150-300 mg/d) for 12 weeks.The improvements of allodynia and head-ache were recorded after 1 and 3 months treatment and the effect of pregabalin on CA was discussed.Side effects of the drug were recorded.Results CA appeared in 65.1%patients with migraine, including thermal CA in 85.4%, static mechanical CA in 29.4%and dynamic CA in 22.0%.CA was associated with gender, duration of illness and medica-tion-overuse.Compared with baseline, pregabalin significantly reduced the severity and the number of patients with all-odynia after 1 and 3 months treatment (P<0.05).The frequency and severity of headache, MIDAS and HIT-6 scores significantly decreased after the treatment of pregabalin for 3 months compared with baseline(P<0.05).The total ther-apeutic effect of pregabalin was 85.4%.Conclusion CA appears in 65.1% patients with migraine.It is associated with gender, duration of illness and medication-overuse.Pregabalin may be effective in relieving allodynia in migraine.