论文部分内容阅读
本文综述了乙型肝炎病毒(HBV)前C区基因突变的研究进展。前C区某些部位,特别是第1896位核苷酸的终止突变,使HBV失去分泌HBeAg的能力,但不影响其复制与传染。前C区突变的发生除与HBV前基因组逆转录过程中缺乏校验酶而发生碱基错配有关外,主要与宿主的免疫压力有关。前C区的突变常伴有其它基因特别是C基因的突变,共同影响突变株的生物学特性及宿主的临床转归,使某些突变株与重症肝炎的发生及干扰素的疗效关系密切,在母婴传播及肝移植中具有特殊意义。
This article reviews the research progress of HBV pre-C gene mutation. Some parts of pre-C region, especially the 1896th nucleotide stop mutation, the loss of HBV secretion of HBeAg capacity, but does not affect its replication and transmission. In addition to the occurrence of pre-C mutation in the pre-HBV genome reverse transcription process of lack of verification of the base mismatch, but mainly with the host immune pressure. Mutations in the pre-C region are often accompanied by mutations in other genes, especially the C gene, affecting the biological characteristics of the mutant and the clinical outcome of the host, making certain mutant strains closely related to the occurrence of severe hepatitis and the efficacy of interferon. In mother-to-child transmission and liver transplantation has a special significance.