本文报告胃镜直视下清创并喷洒胃Ⅱ胶治疗消化性溃疡的经过和结果，并对治疗机理作一初步探讨。作者将１１２例经胃镜确诊的消化性溃疡患者随机分为甲氰咪胍组、胃Ⅱ胶组、复合组（胃Ⅱ胶＋甲氰咪胍），结果有效率分别为：８４．１％、８１．２％、９１．６％。经统计学处理，三组疗效差异无显著性（Ｐ＞０．０５）。该方法使胃镜检查和治疗一次完成，具有简单、方便的特点，且疗效确实，无副作用。 This article reports the debridement and gastric mucosal gastrectomy under the gastroscope direct treatment of peptic ulcer after and the results, and the treatment mechanism for a preliminary study. The 112 patients with peptic ulcer diagnosed by gastroscopy were randomly divided into cimetidine group, stomach Ⅱ plastic group, combined group (stomach Ⅱ glue + cimetidine), the results were 84.1%, respectively, 81.2%, 91.6%. After statistical analysis, there was no significant difference between the three groups (P> 0.05). The method enables gastroscopy and treatment to be completed at one time, has the advantages of simplicity and convenience, and has a curative effect without side effects.