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已知钙离子进入 T 淋巴细胞(TC),是触发 TC 对抗原或植物血凝素(PHA)和刀豆素 A(ConA)起反应的关键。钙阻滞剂(CaA)可通过阻滞钙离子(Ca++)进入细胞而起免疫抑制作用。本文意在验证CAA 是否在体内、外均有免疫抑制作用及其与环孢素(CS)作用的关系。病人和方法 10例肾移植后获得满意肾功能者参加本试验。试验期间 CS 用量不变,平均为4.2mg/kg/d。试验者中5例用尼群地平60mg/d,5例用硫氮酮90mg/d。试验开始前及后4周分别测血 CS水平、周围血淋巴细胞分布以及淋巴细胞在体外对PHA 和美洲商陆(PWM)的反应。结果试验期间10例患者中无1例发生排斥反
It is known that entry of calcium ions into T lymphocytes (TCs) is the key to triggering the reaction of TCs against either antigen or phytohemagglutinin (PHA) and concanavalin A (ConA). Calcium blockers (CaA) play an immunosuppressive role by blocking the entry of calcium ions (Ca ++) into cells. This article is intended to verify whether CAA has an immunosuppressive effect both in vivo and in vitro and its relationship with the effects of cyclosporine (CS). Patients and Methods Ten patients who had satisfactory renal function after kidney transplantation participated in this study. The amount of CS during the experiment unchanged, with an average of 4.2mg / kg / d. Five of the trial participants used nitrendipine 60 mg / day, and 5 patients used diltiazem 90 mg / day. Blood levels of CS were measured before and 4 weeks after the start of the experiment, distribution of peripheral blood lymphocytes, and response of lymphocytes to PHA and Pokeweed in vitro. Results None of the 10 patients had rejection during the trial