为了观察早期高动力脓毒性休克时纳洛酮治疗是否有效,作者设计了一个对照随机研究。选22例性别不论、年满18岁的脓毒性休克病人,收缩期血压(SBP)都在90mm Hg以下,已持续45分钟,并伴有感染(发热>101°F、白细胞增多或经细菌培养证实)。将病人随机安排入纳洛酮组和安慰剂组,每组各11例。纳洛酮组病人在3～5分钟内静脉注射纳洛酮30μg/kg和10mlD5W,接着在60分钟内输注 To see if naloxone treatment is effective in early high-powered septic shock, the authors designed a controlled randomized trial. All 22 patients with septic shock who were 18 years of age or older were eligible for systolic blood pressure (SBP) of 90 mm Hg or less for 45 minutes with infection (fever> 101 ° F, leukocytosis or bacterial culture Confirmed). Patients were randomly assigned to naloxone and placebo, 11 in each group. Naloxone group patients intravenously naloxone 30μg / kg and 10mlD5W within 3 to 5 minutes, followed by infusion within 60 minutes