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纳米载体靶向药物递送系统早已受到各国的广泛关注,虽然这一研究方向的论文发表量呈指数增加,却基本没有成药性.本文基于物理化学和生物学原理分析,通过对不同材料和粒径纳米载体扩散系数的实验研究,探讨分子与纳米粒子在水介质中依数性和扩散能力的差异、纳米载体在体内的寻靶过程,从根本上剖析了纳米载体靶向药物递送系统理论中存在的种种误区,揭示了主动靶向修饰的纳米载体并不能够按照载体设计的初衷提高对肿瘤组织的靶向效率的缺陷.证明EPR效应只适用于药物分子与具有足够扩散能力的纳米载体,并提出依靠环境特异性响应的靶向释药、提高纳米载体扩散能力、利用巨噬细胞固有的吞噬作用捕获NPs实现靶向药物递送以及逐级靶向等更具有可行性的靶向递送新策略.
Nano-carrier targeted drug delivery system has long been widely concerned by all countries, although the number of papers published in this research direction increased exponentially, but basically no drug-induced.In this paper, based on the physical and chemical and biological principles, through the different materials and particle size Nano-carrier diffusion coefficient of the experimental study to explore molecules and nanoparticles in aqueous media according to the number of differences and the ability to diffuse nanocarriers in the body’s homing process, a fundamental analysis of the nano-carrier-based drug delivery system theory exists , Revealing the defects that the active targeting modified nanocarrier can not improve the targeting efficiency of the tumor tissue according to the original intention of the carrier design.It is proved that the EPR effect is only applicable to the drug molecule and the nanocarrier having sufficient diffusion ability and A new strategy of target delivery based on targeted drug delivery with specific response to the environment, improved ability to diffuse nanocarriers, and NPs capture by the phagocytosis of macrophages to achieve targeted drug delivery and step by step targeting are proposed.