哮喘有明显的家族聚集现象,其亲属的患病率明显高于普通人群,表现为气道的高反应性。目前哮喘的遗传基因还不清楚。为了寻找哮喘的相关基因新位点,我们应用微卫星技术,对哮喘家系的第 15、16号染色体进行了染色体特异性基因组扫描,现报告如下。资料和方法:研究对象　研究组 Asthma has obvious familial aggregation, the prevalence of their relatives was significantly higher than the general population, manifested as airway hyperresponsiveness. The current genetic basis of asthma is unclear. In order to search for new loci related to asthma, we applied microsatellite technology to chromosome-specific genomic scanning of chromosomes 15 and 16 of the asthma pedigrees and are reported as follows. Materials and Methods: Study Group