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目的观察丹参注射液联合腹腔镜复位术治疗小儿肠套叠对受累阑尾损伤程度的影响。方法将184例肠套叠患儿随机分为研究组和对照组各92例。对照组采用腹腔镜复位治疗,研究组在对照组治疗基础上联合丹参注射液治疗。对比2组患儿入院时(T1)、术后12h(T2)和术后3d(T3)及术后5d(T4)血清一氧化氮(NO)水平,对比2组阑尾损伤Chiu评分。结果 T1时,2组NO水平差异无统计学意义(P>0.05)。T2时,2组患儿血清NO水平均较T1时段明显升高,之后T3、T4时段血清NO水平逐步下降,且研究组T2、T3、T4时段NO水平低于对照组,差异具有统计学意义(P<0.05)。研究组受累阑尾损伤程度Chiu评分为(2.49±0.25)分明显低于对照组的(4.71±0.32)分,差异有统计学意义(P<0.05)。结论腹腔镜复位术联合丹参注射液治疗小儿肠套叠能够抑制患儿体内NO的合成,恢复NO与氧自由基之间的平衡,对肠缺血再灌注损伤受累阑尾黏膜有明显的保护作用,值得在临床推广应用。
Objective To observe the effect of Salvia miltiorrhiza injection combined with laparoscopic reduction on the degree of appendicitis in children with intussusception. Methods 184 cases of intussusception were randomly divided into study group and control group of 92 cases. The control group was treated with laparoscopic reduction. The study group was treated with Salvia miltiorrhiza injection on the basis of the control group. The levels of serum nitric oxide (NO) at admission (T1), 12h (T2) and postoperative 3d (T3) and 5d after operation (T2) were compared and the Chiu scores of two groups were compared. Results There was no significant difference in NO level between the two groups at T1 (P> 0.05). At T2, serum NO levels in both groups were significantly higher than those in T1, then gradually decreased in T3 and T4, and the levels of NO in T2, T3 and T4 in study group were lower than those in control group (P <0.05). The Chiu score of the appendiceal lesion in the study group was significantly lower than that of the control group (2.49 ± 0.25) (4.71 ± 0.32), with significant difference (P <0.05). Conclusion Laparoscopic reduction combined with Danshen injection in children with intussusception can inhibit the synthesis of NO in children, restore the balance between NO and oxygen free radicals, intestinal ischemia-reperfusion injury appendix appendix mucosa obvious protective effect, Worthy of clinical application.