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目的 探讨产妇与新生儿弓形虫感染的有关危险因素。方法 采用整群抽样的方法共选取住院分娩的产妇 2 84例及其新生儿 2 84例 ,采集产妇静脉血 3ml(分娩前 )及其新生儿脐血 3ml,并进行相应的流行病学个案调查 ;用ELISA法一次性检测弓形虫循环抗原CAg、弓形虫特异性IgG和IgM抗体。结果 产妇阳性 15例 ,产妇总感染率为 5 2 8% ;新生儿阳性 5例 ,新生儿总感染率为 1 76 % ;产妇与动物 (猫、狗、鸡、鸭等 )密切接触史与其新生儿弓形虫感染有非常显著性的统计学联系 (OR =2 8 39,OR95 %CI为 3 5 8～ 10 2 32 ,P <0 0 1)。结论 从优生优育的角度出发非常有必要加强对妊娠期妇女的检测和管理。
Objective To investigate the risk factors of maternal and neonatal toxoplasmosis infection. Methods Two hundred and seventy-eight males and 848 newborns were selected by cluster sampling method. 3 ml of maternal venous blood (before delivery) and 3 ml of neonatal cord blood were collected and the corresponding epidemiological investigation was conducted Toxoplasma gondii recurrent antigen CAg, Toxoplasma gondii-specific IgG and IgM antibodies were detected by ELISA. Results Maternal positive in 15 cases, maternal infection rate was 52.8%; neonatal positive in 5 cases, neonatal total infection rate was 76%; maternal and animal (cats, dogs, chickens, ducks, etc.) close contact history and its newborn Toxoplasma gondii infection had a very significant statistical relationship (OR = 2 8 39, OR 95% CI 358 to 10232, P <0.01). Conclusion From the perspective of prenatal and postnatal care, it is very necessary to strengthen the detection and management of pregnant women.