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1例46岁女性患者,因高脂血症及原发性高血压口服阿司匹林0.1 g,1次/d;阿托伐他汀钙10 mg,1次/d;苯扎贝特0.2 g,2次/d;硝苯地平30 mg,2次/d,共10 d。治疗第8天,患者出现双下肢肌肉疼痛;第9天疼痛蔓延至双侧肩背部、双上肢及全身。随后全身肌肉疼痛加剧,双下肢肌肉僵硬,尿液呈棕红色。血生化检查:肌酸激酶21 507 U/L,肌酸激酶同工酶5460 U/L,乳酸脱氢酶1517 U/L,丙氨酸转氨酶194 U/L,天冬氨酸转氨酶895 U/L,肌酐268μmol/L。给予血液净化、碱化尿液、保护肝肾功能等治疗,患者好转。
One 46-year-old female patient with aspirin 0.1 g, once per day due to hyperlipidemia and essential hypertension, atorvastatin calcium 10 mg once daily, bezafibrate 0.2 g, twice daily / d; nifedipine 30 mg, 2 times / d, a total of 10 d. On day 8 of treatment, the patient developed muscle pain in both lower extremities; on day 9, pain spread to both shoulders, both upper extremities and the whole body. Then systemic muscle pain worsened, both lower limb muscle stiffness, urine was brown red. Blood biochemical tests: creatine kinase 21 507 U / L, creatine kinase isoenzyme 5460 U / L, lactate dehydrogenase 1517 U / L, alanine aminotransferase 194 U / L, aspartate aminotransferase 895 U / L, creatinine 268μmol / L. Give blood purification, alkalinization of urine, liver and kidney protection and other treatment, the patient improved.