手性二级醇作为手性药物、香料等的原料,主要通过不对称加氢来制备.近来通过不对称硅氢加成的方法来制备手性醇的方法,由于其温和的反应条件及相对低廉的催化剂成本而受到广泛关注.介绍了近年来锌、铁、铜、钛等非贵金属催化剂催化潜手性酮的不对称硅氢加成反应的研究进展. Chiral secondary alcohols as chiral drugs, spices and other raw materials, mainly by asymmetric hydrogenation to prepare. Recently by asymmetric hydrosilylation method to prepare chiral alcohol method, due to its mild reaction conditions and relative Low catalyst cost and widespread concern.The progress in the asymmetric hydrosilylation reaction of tramadol catalyzed by non-noble metal catalysts such as zinc, iron, copper and titanium has been introduced in recent years.