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目的 研究胆汁蔓陀罗凝集素结合活力 (DLBA)联合癌胚抗原测定诊断胆管癌的价值。方法 采用酶联凝集素测定法 (ELLA)检测 31例胆管癌及 13例良性胆道疾病胆汁糖蛋白蔓陀罗凝集素 (DSA)结合活力 ,同时采用放免测定法检测CEA水平 ,并评价两种方法对胆管癌的联合诊断价值。结果 胆汁DLBA、CEA的分界值分别为 0 8uDLBA/ml和 7 0ng/ml时 ,DSA ELLA及CEA放免测定诊断胆管癌的阳性率分别为 74 2 %、80 6 % ;特异性均为 10 0 %。联合诊断 (CEA或DLBA升高 )的阳性率为 96 8% ,特异性为 10 0 %。结论 胆汁蔓陀罗凝集素结合活力联合癌胚抗原测定有助于胆管癌的诊断。
Objective To study the diagnostic value of Gallbladder Datura agglutinin binding activity (DLBA) combined with carcinoembryonic antigen in the diagnosis of cholangiocarcinoma. Methods The binding activity of DSA in 31 cases of cholangiocarcinoma and 13 cases of benign biliary disease was detected by enzyme linked immunosorbent assay (ELLA), and the CEA level was detected by radioimmunoassay. Two methods were also evaluated The value of combined diagnosis of cholangiocarcinoma. Results The positive rates of DSA ELLA and CEA for the diagnosis of cholangiocarcinoma were respectively 80% and 80% when the cutoff values of DLBA and CEA were 0 8uDLBA / ml and 70ng / ml, respectively. The specificity was 100% . The combined diagnosis (elevated CEA or DLBA) was 96.8% with a specificity of 10%. Conclusion It is helpful to diagnose cholangiocarcinoma by measuring the activity of agglutinin combined with vitality and carcinoembryonic antigen.