论文部分内容阅读
目的为了解浙江北部小于8月龄幼儿麻疹病例增多的原因,对孕龄妇女麻疹抗体水平进行调查。方法采集外周静脉血分离血清,采用ELISA法和中和实验方法分别检测麻疹IgG抗体和中和抗体的平均水平及阳性率。结果218名孕妇麻疹抗体IgG水平的阳性率为80.7%,与麻疹分离野毒株的中和抗体几何平均滴度为30.36±4.70,其中中和抗体<1∶2的阴性样本占16.51%,<1∶8者所占比例为19.27%,≥1∶16者所占比例为73.39%。结论孕妇人群中麻疹低滴度抗体会影响母传抗体的维持时间,这很可能和近年来麻疹爆发表现为成人和低月龄儿病例,尤其是未满8月龄婴幼儿病例增多有极大的关系。
Objective To understand the reasons for the increase of measles cases in infants less than 8 months of age in northern Zhejiang province, the antibody levels of measles in pregnant women were investigated. Methods Peripheral venous blood was collected for serum separation. The mean and positive rates of measles IgG and neutralizing antibodies were detected by ELISA and neutralization assay respectively. Results The positive rate of measles antibody IgG in 218 pregnant women was 80.7%. The geometric mean titer of neutralizing antibodies against measles isolates was 30.36 ± 4.70. The negative samples with neutralizing antibody <1: 2 accounted for 16.51% 1: 8, the proportion of 19.27%, ≥ 1: 16, the proportion of 73.39%. Conclusions Low measles antibody levels in pregnant women may affect the maintenance of mother-of-antibodies, which is likely to be related to the outbreak of measles in adults and low-age infants in recent years, especially in infants younger than 8 months Relationship.