各种因素如创伤应激、重症感染及休克等均可导致胃肠功能障碍,严重感染则是临床中常见的因素之一。细菌、内毒素通过增加肠上皮细胞凋亡、坏死,抑制肠道免疫功能,破坏肠屏障及其修复功能等使肠道通透性增加,肠源性细菌、毒素入血并转移至远隔器官,而最终出现多系统器官功能衰竭。 A variety of factors such as trauma stress, severe infection and shock can lead to gastrointestinal dysfunction, severe infection is one of the common clinical factors. Bacteria and endotoxins increase intestinal permeability by increasing intestinal epithelial cell apoptosis and necrosis, inhibiting intestinal immune function, destroying the intestinal barrier and its repair function, etc. enterogenic bacteria and toxins enter the bloodstream and transfer to distant organs , And eventually multi-system organ failure.