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近年来微型胶囊(又称微囊)这一新剂型已十分引人注目。在医药方面主要作为非口服剂型,特别是通过缓释注射剂可有效地将药物输入靶器官和作用部位。本文主要叙述微囊,并简要介绍毫微囊、脂质体和白蛋白微粒体等。微型胶囊1964年 Chang 制备了尿素酶微囊(以尼龙为壁膜),该微囊注射到腹腔或肌肉时能显著降低毒性,并能延长酶的作用。据报道,若胶囊膜内外吸附肝素和季铵盐的复合体,有可能防止胶囊在血管内形成血栓。
In recent years, micro-capsules (also known as microcapsules) this new dosage form has attracted great attention. In medicine, mainly as a non-oral dosage form, especially through the slow release of injection can be effective drugs into the target organ and site of action. This article describes the microcapsules, and briefly introduces nanocapsules, liposomes and albumin microsomes. Microcapsules In 1964, Chang prepared a urease microcapsule (with nylon as the wall membrane) that significantly reduces toxicity and prolongs enzyme activity when injected into the abdominal cavity or muscle. It is reported that if the capsule membrane adsorbed heparin and quaternary ammonium complexes inside and outside, it is possible to prevent the formation of blood vessels in the capsule thrombus.