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SMADs是细胞内信号传递通路中的胞浆递质 ,调节细胞生长、分化。SMADs在癌细胞中常发生突变 ,可能与癌发生发展有关 ,尤其是SMAD4在胰腺癌、直肠结肠癌中突变率较高 ,可能是有效的肿瘤抑制信号。
SMADs are cytoplasmic transmitters in intracellular signaling pathways that regulate cell growth and differentiation. SMADs are often mutated in cancer cells and may be related to carcinogenesis. In particular, SMAD4 has a high mutation rate in pancreatic cancer and rectal cancer and may be an effective tumor suppressor signal.