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观察了１／４，１／２和３／４肾切除大鼠术后第１０周血清锌、铜水平及肾功能、血浆白蛋白和尿蛋白，并与行假手术未切除肾脏的动物相比较，发现１／４和１／２肾切除动物血清锌铜无明显变化，而３／４肾切除的动物发生了肾功能衰竭，出现显著的蛋白尿和低蛋白血症，血清锌、铜均下降。相关性分析表明血清锌与血浆白蛋白呈正相关，与尿蛋白呈负相关，而Ｓｃｒ和ＢＵＮ无明显相关，血清铜则与这些测定值不显示明显相关。研究提示肾组织缺失时血清锌降低可能是由于其载体———白蛋白的减少及随尿蛋白的大量丢失所致，而可能不受Ｓｃｒ和ＢＵＮ的影响。血清铜水平降低的机制有待于进一步研究
The levels of serum zinc, copper, renal function, serum albumin and urinary protein were observed in 1/4, 1/2 and 3/4 nephrectomy rats at the 10th week after operation, compared with those of the sham-operated non-excised kidneys , Found no significant changes in serum zinc and copper in 1/4 and 1/2 nephrectomy animals, and 3/4 nephrectomy animals with renal failure, significant proteinuria and hypoproteinemia, serum zinc, copper decreased . Correlation analysis showed that serum zinc was positively correlated with plasma albumin and negatively correlated with urinary protein, while Scr and BUN had no significant correlation. Serum copper did not show significant correlation with these measured values. Research suggests that serum zinc levels in the absence of renal tissue may be due to a decrease in its carrier, albumin, and a significant loss of urine protein, which may not be affected by Scr and BUN. The mechanism of serum copper level reduction remains to be further studied