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为寻找血小板聚集抑制剂,对多种植物提取物进行了评价。发现中药决明具有抗磷酸腺苷(ADP),抗花生四烯酸(AA)、抗胶原(collagen)诱导的血小板聚集作用。决明中的三个蔥醌类化合物aurantioobtusin(12),chrysoobtusin(14)和emodin(8)前曾报道显示抗血小板聚集的活性,但它们的抑制活性相当微弱,作者认为在该植物中可能还有其他活性成分存在。因此,对决明种子的提取物作了进一步的研究。从中又发现厂三个蔥醌糖甙类化合物gluco-obtusifolin(11).gluco-auzran
In order to find platelet aggregation inhibitors, various plant extracts were evaluated. Found that traditional Chinese medicine Cassia anti-adenosine monophosphate (ADP), anti-arachidonic acid (AA), anti-collagen (collagen) induced platelet aggregation. The three onion compounds aurantioobtusin(12), chrysoobtusin(14), and emodin(8) in Cassia were previously reported to show anti-platelet aggregation activity, but their inhibitory activity was quite weak, and the authors believe that this plant may also have There are other active ingredients. Therefore, a further study was performed on the extract of seeds of Cassia. From this we discovered another three green glycosides gluco-obtusifolin(11).gluco-auzran