AIM:Capsule endoscopy has demonstrated its clinical utilityin the evaluation of small bowel pathology in several Westernstudies.In this prospective study,we aimed to determinethe clinical utility,safety and tolerability of capsule endoscopyin the evaluation of suspected small bowel disease in anurban Southeast Asian population.METHODS:We used the given (M2A) capsule endoscopysystem in 16 consecutive patients with suspected small bowelpathology.In 9 patients the indication was obscuregastrointestinal bleeding,while in 6 patients it was todetermine the extent of small bowel involvement in Crohn’sdisease.One patient underwent capsule endoscopy forevaluation of chronic abdominal pain.Patient’s tolerabilityto the procedure was evaluated by standardized questionnairesand all patients were reviewed at one week to ensure thatthe capsule had been excreted without any adverse events.RESULTS:Abnormal findings were present in 8 patients(50%).The cause of obscure gastrointestinal bleeding wasdetermined in 5 out of 9 patients.Findings included 2 casesof angiodysplasia,2 cases of jejunal ulcers and 1 case ofboth angiodysplasia and jejunal ulcer.One patient had smallbowel erosions and loci of erythema of doubtful significance.Ileal lesions were diagnosed in 2 out of 6 patients withCrohn’s disease.Capsule endoscopy was well tolerated by allpatients.One patient with Crohn’s disease had a complicationof capsule retention due to terminal ileum stricture.Thecapsule eventually passed out spontaneously after i month.CONCLUSION:Our study,which represented the first Asianseries,further confirms the diagnostic utility,safety andtolerability of wireless capsule endoscopy. AIM: Capsule endoscopy has demonstrated its clinical utility in the evaluation of small bowel pathology in several Western studies. In this prospective study, we aimed to determine the clinical utility, safety and tolerability of capsule endoscopy in the evaluation of suspected small bowel disease in anurban Southeast Asian population. METHODS: We used the given (M2A) capsule endoscopysystem in 16 consecutive patients with suspected small bowel pathology. In 9 patients the indication was obscuregastrointestinal bleeding, while in 6 patients it was todetermine the extent of small bowel involvement in Crohn’s disease. One patient underwent capsule endoscopy forevaluation of chronic abdominal pain. Patients statable and all patients were reviewed at one week to ensure that the capsule had been excreted without any adverse events .RESULTS: Abnormal findings were present in 8 patients (50%). The cause of obscure gastrointestinal bleeding wasdeterm ined in 5 out of 9 patients. Findings included 2 cases of angiodysplasia, 2 cases of jejunal ulcers and 1 case ofboth angiodysplasia and jejunal ulcer. One patient had small bowel erosions and loci of erythema of doubtful significance. Elemental lesions were diagnosed in 2 out of 6 patients with Crohn’s disease. Capsule endoscopy was well tolerated by allpatients. One patient with Crohn’s disease had a complication of capsule retention due to terminal ileum stricture. The culmination eventually passed out spontaneously after i month. CONCLUSION: Our study, which represented the first Asian series, further confirms the diagnostic utility, safety andtolerability of wireless capsule endoscopy.