目的:分析四川东北部地区新型冠状病毒肺炎（新冠肺炎）患者的流行病学和临床特征及治疗情况，及时总结经验，为临床诊疗新冠肺炎提供参考。方法:采用回顾性研究方法，选择2020年1月27日至2月9日巴中市中心医院和达州市中心医院收治的59例新冠肺炎确诊患者。收集患者的人口学资料、流行病学资料、实验室检查资料、胸部CT资料和相关临床治疗资料，按照疾病严重程度将患者分为轻型、普通型和重型，比较不同临床分型患者上述指标的差异。结果:①一般资料及流行病学：患者中男性31例（占52.5%），女性28例（占47.5%）；平均年龄（42.0±16.4）岁，40岁以上中老年人占比最多，为59.3%（35例）；临床分型以普通型患者为主，占72.9%（43例）；病例来源以输入性为主，占62.7%（37例）。随着临床分型加重，患者平均年龄也呈明显增加趋势〔轻型、普通型和重型分别为（30.9±13.6）、（42.7±15.3）、（55.8±18.9）岁，n P<0.01〕；重型患者中合并1种以上基础疾病的比例明显高于轻型和普通型〔66.7%（4/6）比20.0%（2/10）、9.3%（4/43），均n P<0.01〕；临床症状分布中，重型患者胸闷/呼吸困难的比例明显高于轻型和普通型〔66.7%（4/6）比10.0% （1/10）、11.6% （5/43），均n P<0.05〕。②实验室检查指标：与轻型和普通型患者比较，重型患者白细胞计数（WBC）、中性粒细胞计数（NEU）和C-反应蛋白（CRP）水平均较高〔WBC（×10n 9/L）：7.21±4.35比5.85±1.69、5.43±2.04，NEU（×10n 9/L）：6.09±4.43比3.95±1.45、3.54±1.83，CRP（mg/L）：16.00（8.20，46.43）比5.00（0.00，16.13）、15.00（3.13，28.58）〕，而白蛋白（Alb）水平较低（g/L：38.00±5.35比49.23±5.27、39.81±2.15，均n P<0.05）；轻型患者的血红蛋白（Hb）水平明显高于重型和普通型（g/L：155.2±12.1比141.3±6.8、131.1±11.7，均n P<0.05）。③胸部影像学：典型病例的胸部CT表现为单发或多发磨玻璃密度影，随着病情进展，病灶逐渐增多、范围逐步扩大，并累及至多个肺叶的实变阴影。④治疗：患者均接受至少2种及以上的抗病毒治疗，重型患者干扰素、利巴韦林的应用率较轻型和普通型更高〔100.0%（6/6）比80.0%（8/10）、97.7%（42/43），83.3%（5/6）比0%（0/10）、20.9%（9/43），均n P<0.05〕。⑤预后：截至2020年3月6日，有50例（占84.8%）患者康复出院，其余9例仍在接受治疗中，无死亡患者。n 结论:新冠肺炎重型患者胸闷/呼吸困难的比例更高，年龄越大、合并基础疾病越多的患者进展为重型的可能性也越高；疑似病例甚至发热患者高分辨率胸部CT表现可提示病情进展。“,”Objective:To analyze the epidemiological, clinical characteristics and treatment of coronavirus disease 2019 (COVID-19) in Northeastern Sichuan, and summarize experience in time to provide reference for clinical diagnosis and treatment.Methods:A retrospective study was conducted. Fifty-nine patients with COVID-19 admitted to Bazhong Central Hospital and Dazhou Central Hospital from January 27th to February 9th, 2020 were selected as the subjects. The data of demography, epidemiology, laboratory examination, chest CT and related clinical treatment were collected. According to the severity of the disease, the patients were divided into three types: mild, general and severe types, and the differences of the above indices among different clinical types were compared.Results:① General information and epidemiology: 31 cases (52.5%) were male, 28 cases (47.5%) were female, the average age was (42.0±16.4) years old, and the patients over 40 years old accounted for the largest proportion (35 cases, 59.3%). The proportion of clinical type was 72.9% (43 cases) in general type, and 62.7% (37 cases) were imported type. With the increase of disease severity, the average age of patients also showed a significant increase trend [the age of the mild, general and severe patients were (30.9±13.6), (42.7±15.3), (55.8±18.9) years old, n P < 0.01]. The proportion of patients with more than one basic disease in severe patients was significantly higher than those in mild and general patients [66.7% (4/6) vs. 20.0% (2/10), 9.3% (4/43), both n P < 0.05]. In the distribution of clinical symptoms, the proportion of severe patients with chest distress/dyspnea was significantly higher than those in mild and general patients [66.7% (4/6) vs. 10.0% (1/10), 11.6% (5/43), both n P < 0.05]. ② Laboratory examination index: the total number of white blood cell count (WBC), neutrophils count (NEU), C-reactive protein (CRP) in severe patients were higher than those in mild patients and general patients [WBC (×10 n 9/L): 7.21±4.35 vs. 5.85±1.69, 5.43±2.04; NEU (×10n 9/L): 6.09±4.43 vs. 3.95±1.45, 3.54±1.83; CRP (mg/L): 16.00 (8.20, 46.43) vs. 5.00 (0.00, 16.13), 15.00 (3.13, 28.58)], the albumin (Alb) level in severe patients was lower than those in mild and general patients (g/L: 38.00±5.35 vs. 49.23±5.27, 39.81±2.15, both n P < 0.05), while the hemoglobin (Hb) level in mild patients was higher than that in severe and general patients (g/L:155.2±12.1 vs. 141.3±6.8, 131.1±11.7, both n P < 0.05). ③ Chest imaging: the CT manifestations of typical cases were single or multiple ground glass shadows. With the progress of the disease, the focus gradually increased, the scope gradually expanded, and multiple solid shadows of lung lobes were involved. ④ Treatment: all patients received at least 2 kinds of antiviral therapy, and the application rate of Interferon and Ribavirin in severe patients were higher than those in mild and general patients [100.0% (6/6) vs. 80.0% (8/10), 97.7% (42/43); 83.3% (5/6) vs. 0% (0/10), 20.9% (9/43); all n P < 0.05]. ⑤ Prognosis: until March 6th 2020, 50 patients (84.8%) were discharged from the hospital after rehabilitation, and the remaining 9 patients were still under treatment, none deaths.n Conclusions:The proportion of severe patients with chest distress/dyspnea is higher, the older the patients are and the more basic diseases are, the more likely they are to develop into severe type. High resolution chest CT could be considered for suspected cases or even fever patients, which may show the progress of the disease.