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58例癌症及20例良性病变患者手术或免疫疗法前后 NK 活性动态比较,结果提示:(1)胃良性病变组术前低下明显,术后恢复正常。(2)结直肠良性病变组手术前后均正常。(3)胃癌及结直肠癌二组术前低下明显,术后可见回升。(4)结直肠癌干扰素—α治疗组,用药前后差别明显。(5)LAK 细胞或TIL/IL—2晚期癌症治疗组,疗前低下明显,疗后皆呈上升趋势,并与抗癌疗效呈正比。表明 NK 活性测定是一项癌症免疫监测指标,有助于癌症诊断及抗癌方案的选择。
The dynamic comparison of NK activity in 58 cases of cancer and 20 cases of benign lesions before and after surgery or immunotherapy suggested that: (1) The benign gastric lesions were significantly lower before surgery and returned to normal after surgery. (2) Colorectal benign lesions were normal before and after surgery. (3) Gastric cancer and colorectal cancer were significantly lower in preoperative and postoperative recovery. (4) In the colorectal cancer interferon-alpha treatment group, the differences were significant before and after administration. (5) The LAK cells or TIL/IL-2 advanced cancer treatment group showed significant reduction before treatment and showed an upward trend after treatment, which was in direct proportion to the anticancer efficacy. It indicates that NK activity assay is an indicator of cancer immune monitoring and is helpful for the diagnosis of cancer and the selection of anti-cancer programs.