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采用时间毒理学方法，研究锌对铅诱发大鼠脂质过氧化昼夜节律的影响。结果显示：正常大鼠体内脂质过氧化物（ＬＰＯ）含量具有近似昼夜节律，以１４∶１４为峰值，０２∶１４为谷值。经不同剂量醋酸铅染毒后，３个剂量组大鼠体内ＬＰＯ含量均比对照增高，呈明显的剂量效应关系；且昼夜节律消失。经硫酸锌联合处理后，３个剂量组大鼠体内ＬＰＯ含量均比单独铅染毒的相应剂量组低；且低剂量铅组ＬＰＯ含量的昼夜节律重新出现，但峰值相位提前５小时。提示铅对机体的脂质过氧化作用具有时间毒性，锌对低剂量铅所诱发的脂质过氧化时间毒性具有一定的拮抗作用
Time toxicology method was used to study the effect of zinc on the circadian rhythm of lipid peroxidation induced by lead in rats. The results showed that the normal rat body lipid peroxide (LPO) content has a similar circadian rhythm, with 14:14 as the peak, 02:14 as the valley. After exposure to different doses of lead acetate, the LPO content in the three dose groups was higher than that in the control group, showing a significant dose-effect relationship; and the circadian rhythm disappeared. After combined treatment with zinc sulfate, the LPO content in the three dose groups was lower than that in the lead-exposed group alone. The circadian rhythm of LPO content in the low-dose lead group reappeared, but the peak phase was advanced by 5 hours. Prompted lead on the body of lipid peroxidation with time toxicity, zinc on low-dose lead-induced lipid peroxidation time toxicity has some antagonism