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人胆汁中的免疫球蛋白(Ig)由Tomasi在1963年首次测得。由于它在胆道、肠道免疫中的特殊作用,这一含量并不高的胆汁成分日益引起人们的重视。研究重点在于胆汁Ig的含量、来源、免疫学特性及其在肝胆乃至肠道免疫中的地位。胆汁Ig含量及免疫化学特性正常人和动物胆汁中均有Ig存在,啮齿类动物以IgA占优势,人胆汁中各类Ig含量由于测定方法及局部病理生理状态不同而有较大差异。Tomasi等报告胆汁各类Ig的含量顺次为IgG、IgA、IgM,IgG与IgA之比为2.6∶1;另一些作者报告胆汁Ig以IgA为主,约占Ig总量的50%,而IgG占35%,IgM占15%。免疫化学分析证明胆汁IgA与血浆IgA不同,以分泌型IgA占绝对优势,其中约60%是含分泌片(SC)的分泌型IgA(sIgA),不含SC的IgA二聚体(dIgA)占21～33%,其余
Immunoglobulin (Ig) in human bile was first measured by Tomasi in 1963. Due to its special role in the biliary tract and intestinal immune system, the biliary component with a low content is drawing more and more attention. Research focuses on the content of bile Ig, its origin, immunological characteristics and its role in hepatobiliary and intestinal immune. Bile Ig content and immunochemical properties of normal human and animal bile Ig exist, rodents dominated by IgA, various types of human bile Ig content due to the determination of the method and the local pathophysiological state are quite different. Tomasi and other reports of various types of bile Ig followed by IgG, IgA, IgM, IgG and IgA ratio of 2.6: 1; some other authors report that IgA IgA-based, accounting for about 50% of the total Ig, and IgG 35%, IgM 15%. Immunochemical analysis showed that bile IgA was different from IgA in plasma and accounted for the absolute predominance of secretory IgA, of which about 60% were secretory IgA (sIgA) with secreted sheet (SC) and dAgA without SC 21 ~ 33%, the rest