论文部分内容阅读
目的：为研究强化环境训练对低碘鼠学习能力、脑ＤＮＡ及胆碱能神经元相关酶类活性的影响。方法：自缺碘大鼠生后２５天起给予强化环境训练，１５天后测定其学习能力、各脑区ＤＮＡ含量及胆碱能神经元相关酶活性。结果：训练低碘鼠与非训练低碘鼠比较，学习能力，海马、小脑的ＣＨＡＴ活性，大脑皮层、海马的ＡＣＨＥ活性和不可提取ＡＣＨＥ活性百分比，均有明显增高，但仍低于正常对照水平。结论：强化环境训练虽对各脑区神经细胞数目无明显影响，但对神经元的功能活动和精细结构的重建可能具有积极作用，使学习能力得以提高，各脑区胆碱能神经元功能活动尤其是突触部分得以改善
OBJECTIVE: To investigate the effects of enhanced environmental training on learning ability of low iodine-deficient mice and the activity of enzymes related to brain DNA and cholinergic neurons. Methods: Idiopathic rats were given intensive environmental training 25 days after birth, and their learning ability, DNA content in each brain region and enzyme activity of cholinergic neurons were measured after 15 days. Results: Compared with non-trained low iodine group, learning ability, CHAT activity in hippocampus and cerebellum, ACHE activity in cerebral cortex and hippocampus, and percentage of non-extractable ACHE activity were significantly increased, but still lower than the normal control . CONCLUSION: Although intensive training in environment has no obvious effect on the number of nerve cells in each brain region, it may play a positive role in the functional activity of neurons and the reconstruction of fine structures, which can improve the learning ability. The functional activities of cholinergic neurons In particular, synapses are improved