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22例原发性肾病综合征（PNS）肾病期患儿血清白介素6（IL－6）、肿瘤坏死因子α（TNF－α）浓度明显高于缓解组及健康对照组；肾炎型IL－6、TNF-α浓度较单纯型明显增高，缓解组浓度与对照组比较无显著性差异；血清IL－6、TNF－α浓度和尿蛋白排泄量呈正相关，与血清白蛋白浓度呈负相关。提示血清IL-6、TNF－α浓度升高可作为PNS活动的指标。
The levels of serum IL-6 and TNF-α in 22 nephrotic stage patients with primary nephrotic syndrome (PNS) were significantly higher than those in remission and healthy controls. Nephritis IL-6, Compared with the control group, the concentrations of TNF-α and TNF-α in the remission group were not significantly different. Serum levels of IL-6 and TNF-α were positively correlated with urinary protein excretion and negatively correlated with serum albumin. Tip serum IL-6, TNF-α concentration can be used as an indicator of PNS activity.