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近日,一项刊登于国际杂志Journal of Biological Chemistry上的研究报告中,来自日本名古屋大学的研究人员利用线虫作为模式动物进行研究,鉴别出了2型糖尿病药物二甲双胍的新型靶点,研究者发现,在果蝇机体中离子交换蛋白NHX-5和其相关的蛋白质或许是潜在的二甲双胍的靶点,这就表明二甲双胍能够控制细胞内吞作用的周期。2型糖尿病是一种常见的糖尿病类型,患者主要特点表现为胰岛素耐受性及高血糖,很多患者都服用二甲双胍药物来进行治疗,二甲双胍能
In a recent study published in the journal Journal of Biological Chemistry, researchers from Japan’s Nagoya University used nematodes as a model animal to identify new targets of the type 2 diabetes drug metformin. The researchers found that, The ion exchange protein NHX-5 and its related proteins in Drosophila may be potential targets of metformin, suggesting that metformin is capable of controlling the period of endocytosis. Type 2 diabetes is a common type of diabetes that is characterized by insulin resistance and hyperglycemia, and many patients are treated with metformin, and metformin