E-钙粘蛋白和基质金属蛋白酶-7的蛋白表达与大肠癌的相关性

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目的探讨E-钙粘蛋白(E-cadherin)和基质金属蛋白酶-7(MMP-7)的蛋白表达与大肠癌的关系。方法应用免疫组织化学技术检测E-cadherin和MMP-7蛋白在14例大肠腺瘤组织、102例大肠癌组织及相应癌旁正常黏膜的表达情况。结果相对于大肠癌旁的正常组织,E-cadherin在癌组织中表达降低(P〈0.001),而MMP-7蛋白在癌组织中比正常组织表达明显增高(P〈0.001);二者在癌组织中呈现负相关(r=-0.478,P〈0.001)。结论 E-cadherin的表达降低和MMP-7的表达
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