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目的探讨比较米非司酮和去氧孕烯炔雌醇对功能失调性子宫出血的治疗效果。方法本次研究以本院2010年6月~2012年6月期间收治的130例功能失调性子宫出血患者,将其随机分为两组,A组米非司酮组治疗;B组为去氧孕烯炔雌醇治疗,每组各65例。治疗5个月后进行随访,比较两组患者的调经效果、治疗前后子宫内膜厚度、肝功能、是否有副作用以及治疗效果。结果米非司酮组在治疗期间可以有效止血、复发2例(3.07%);去氧孕烯炔雌醇治疗组亦可有效止血,但停止用药后有撤退性出血,复发6例(9.23%)。两组患者经治疗后子宫内膜厚度均变薄,贫血均有不同程度改善。另米非司酮组在FSH、LH、E2和P等指标较之治疗前均有下降。结论米非司酮组在治疗功能失调性子宫出血比去氧孕烯炔雌醇疗效更佳、更安全可靠。
Objective To investigate the therapeutic effect of mifepristone and deoxygestrel ethinyl estradiol on dysfunctional uterine bleeding. Methods In this study, 130 patients with dysfunctional uterine bleeding who were treated in our hospital from June 2010 to June 2012 were randomly divided into two groups: group A, mifepristone; group B, Pregnancy ethinyl estradiol treatment, 65 cases in each group. After 5 months of treatment, follow-up was conducted to compare the effects of menstruation, endometrial thickness before and after treatment, liver function, side effects and the therapeutic effect between the two groups. Results The mifepristone group was effective in stopping bleeding and relapse in 2 cases (3.07%) during the treatment. Desogestrel and ethinyl estradiol treatment group was also effective in stopping bleeding, but there was withdrawal bleeding after stopping administration. The recurrence occurred in 6 cases (9.23% ). After treatment, both groups of patients with endometrial thickness thinning, anemia have varying degrees of improvement. Another mifepristone group FSH, LH, E2 and P and other indicators were lower than before treatment. Conclusion The mifepristone group is more effective and safer to treat dysfunctional uterine bleeding than dehydrogesterone ethinyl estradiol.