目的:分析万古霉素体外诱导后,MRSA与MSSA对万古霉素MIC有无差异。方法:在体外用万古霉素对15株金葡菌进行耐药诱导;诱导后比较MRSA与MSSA对万古霉素的MIC值。结果:有2株MRSA和1株MSSA对万古霉素产生中介耐药,诱导后MRSA与MSSA对万古霉素MIC均值无明显差异。结论:在体外诱导时MRSA与MSSA对万古霉素皆可产生耐药,难易程度无明显差异。 OBJECTIVE: To analyze whether there is any difference in vancomycin MIC between MRSA and MSSA induced by vancomycin in vitro. Methods: Fifteen Staphylococcus aureus strains were induced with vancomycin in vitro. The MIC values ​​of MRSA and MSSA against vancomycin were compared after induction. Results: Two strains of MRSA and one strain of MSSA were resistant to vancomycin. There was no significant difference in mean values ​​of vancomycin between MRSA and MSSA after induction. Conclusion: Both MRSA and MSSA can be resistant to vancomycin when induced in vitro, with no significant difference in ease.