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目的:探讨母婴间HLA-Cw基因多态性与子痫前期的相关性。方法:采集117例子痫前期患者和106例正常孕妇外周血及其胎儿脐带血,提取DNA后采用PCR-SSP方法测定孕妇及胎儿的HLA-Cw基因型进行统计分析。结果:子痫前期组孕妇HLA-Cw12的频率(19/234)要显著高于正常孕妇组孕妇(7/212),子痫前期组母儿共携带HLA-Cw12基因的频率(13/117)显著高于正常晚孕组(4/106),差异均有统计学意义(P0.05)。结论:HLA-Cw12的基因多态性可能与子痫前期的发病相关。“,”Objective:To explore the correlation between gene polymorphism of maternal-fetal human leukocyte antigen-Cw(HLA-Cw) and preeclampsia.Methods:The peripheral blood samples of 117 patients with preeclampsia and 106 normal pregnant women and umbilical cord samples of their fetuses were collected,PCR-SSP method was used to statistically analyze HLA-Cw genotypes of pregnant women and their fetuses after Abstracting DNA.Results:The frequency of HLA-Cw12 in pregnant women in preeclampsia group(19/234) was statistically significantly higher than that in normal pregnancy group(7/212),the frequencies of HLA-Cw12 in pregnant women and their fetuses in preeclampsia group(13/117) were statistically significantly higher than those in normal pregnancy group(4/106)(P0.05).Conclusion:HLA-Cw12 gene polymorphism may be correlated with onset of preeclampsia.