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目的 :为进一步揭示蝎毒活性肽的抗栓机制。方法 :比浊法测定血小板聚集程度、电刺激法复制大鼠颈动脉血栓模型、放免法测定大鼠血浆中 6 keto PGF1α和TXB2 水平。结果 :蝎毒活性多肽 (SVAPs) 0 .12 5 ,0 .2 5 ,0 .5mg·mL-1对体外凝血酶 0 .0 3μ·mL-1,ADP 10 μ·mL-1诱导的血小板聚集有明显的抑制作用 (P <0 .0 5或 0 .0 1) ,且呈量效关系。舌静脉给药 ,大鼠颈动脉血流阻塞时间延长 (P <0 .0 5或 0 .0 1)。结论 :SVAPs抗栓作用可能与其抗血小板聚集 ,升高PGI2 /TXA2 比值及促进纤溶作用有关
Purpose : To further reveal the antithrombotic mechanism of scorpion venom active peptides. Methods: The nephelometric method was used to measure the platelet aggregation, the rat model of carotid artery thrombosis was duplicated by electrical stimulation and the radioimmunoassay was used to determine the levels of 6 keto PGF1α and TXB2 in rat plasma. RESULTS: Thrombolytic aggregation induced by thrombolytic enzyme 0.03 μ·mL-1 and ADP 10 μ· mL-1 in vitro with scorpion-resistant active peptides (SVAPs) 0.125, 0.25, and 0.5 mg·mL-1. There was a significant inhibitory effect (P <0.05 or 0.01) and a dose-effect relationship. With tongue venous administration, the carotid artery obstruction time was prolonged (P <0.05 or 0.01). Conclusion: Antithrombotic effects of SVAPs may be related to their antiplatelet aggregation, elevation of PGI2/TXA2 ratio, and promotion of fibrinolysis.