乳腺癌干细胞是乳腺癌组织中极少数具自我更新能力和多向分化潜能的细胞,与乳腺癌的发生发展密切相关。CD44、CD24、B38.1和ESA等表型标志物和标记滞留细胞、侧亚群细胞、细胞内乙醛脱氢酶1等功能性标志物可为乳腺癌干细胞提供重要的分离和纯化依据,与乳腺癌的转移和预后密切相关,对于研究乳腺癌的生物学特征、调控机制以及靶向治疗有着重要意义。 Breast cancer stem cells is a very small number of breast cancer cells with self-renewal capacity and multi-directional differentiation of cells, and the occurrence and development of breast cancer are closely related. Functional markers such as phenotypic markers such as CD44, CD24, B38.1 and ESA, as well as markers of retained cells, lateral subpopulations, and intracellular acetaldehyde dehydrogenase 1 may provide an important basis for the isolation and purification of breast cancer stem cells. Which is closely related to the metastasis and prognosis of breast cancer. It is of great significance to study the biological characteristics, regulation mechanism and targeted therapy of breast cancer.