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目的 观察急性冠状动脉综合征(ACS)患者血清类金属蛋白酶-9(MMp-9)及C反应蛋白(CRP)水平的变化并与稳定型心绞痛患者比较,分析MMp-9及CRP与ACS的关系。方法 67例经冠状动脉造影证实为冠心病患者分为稳定型心绞痛及ACS二组,分别测定MMp-9及CRP的血清水平并进行分析。结果 ACS患者MMp-9及CRP水平较稳定型心绞痛组明显增高,分别为(329.90±200.10)ng/L、(644.50±251.69)ng/L及(12.83±8.06)mg/L、(37.49±34.60)mg/L,P<0 001,差异有统计学意义。结论 MMp-9及CRP参与了ACS的发生发展过程。
Objective To observe the changes of serum levels of metalloproteinase-9 (MMP-9) and C-reactive protein (CRP) in patients with acute coronary syndrome (ACS) and to compare the relationship between MMp-9, CRP and ACS with patients with stable angina . Methods Sixty-seven patients with coronary heart disease confirmed by coronary angiography were divided into stable angina pectoris group and ACS group. Serum levels of MMp-9 and CRP were measured and analyzed respectively. Results The levels of MMp-9 and CRP in patients with ACS were significantly higher than those in patients with stable angina (329.90 ± 200.10 ng / L, 644.50 ± 251.69 ng / L and 12.83 ± 8.06 mg / L, respectively, and those were 37.49 ± 34.60 ) mg / L, P <0 001, the difference was statistically significant. Conclusion MMp-9 and CRP are involved in the occurrence and development of ACS.