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小剂量三尖杉醋碱(LD-Harr)与小剂量阿糖胞苷(LD-Ara-c)联合治疗ANLL患者10例。在治疗期间,末梢血液和骨髓中原始细胞减少或消失时,伴有短暂的成熟中性粒细胞增多,且在其中见有Auer小体。新鲜分离ANLL患者的骨髓白血病细胞,加Harr和Ara-c进行液体培养后,白血病细胞分化为成熟的粒细胞,在其中也见有Auer小体。治疗结果,10例中有8例完全缓解,1例部分缓解,1例未缓解、副作用较轻。
10 patients with ANLL were treated with LD-Harr at low dose and LD-Ara-c at low dose. During treatment, peripheral blood and bone marrow in the reduction or disappearance of primitive cells, accompanied by transient increase in mature neutrophils, and in which Auer bodies are seen. Freshly isolated ANLL patients with myeloid leukemia cells, liquid culture with Harr and Ara-c, the leukemia cells differentiated into mature granulocytes, in which Auer bodies are also seen. Treatment results, 8 cases of complete remission in 10 cases, 1 case of partial remission, 1 case did not alleviate the side effects.