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目的观察神经生长因子(m NGF)对双瘫后痉挛的治疗效果。方法选取该院2012年1月—2014年3月收治的双瘫恢复早期伴痉挛患儿66例,随机分为治疗组和对照组各33例,对照组给予常规康复训练,治疗组在对照组的基础上加用m NGF。用改良Ashworth(MAS)评分评定痉挛,简易Fugl–Meyer(FMA)评分评定运动功能。结果治疗后两组患儿痉挛和运动功能较治疗前均明显改善,其中治疗组患侧上肢、下肢MAS评级与FMA评分均优于对照组,组间差异有显著性意义,差异有统计学意义(P<0.05);治疗组改善痉挛总有效率:上肢75.8℅,下肢75.8℅,分别优于对照组51.6℅和51.6℅,组间差异有显著性意义,差异有统计学意义(P<0.05)。结论治疗组在改善双瘫患儿的痉挛方面效果明显优于对照组,m NGF可以明显改善双瘫患儿的上下肢痉挛。
Objective To observe the therapeutic effect of nerve growth factor (m NGF) on post-diplegia spasticity. Methods Sixty-six children with early spastic paraplegia who were admitted to our hospital from January 2012 to March 2014 were randomly divided into treatment group and control group, with 33 cases in each group. The control group was given routine rehabilitation training. In the control group Based on the addition of m NGF. Spasticity was assessed using modified Ashworth (MAS) score and motor function assessed by simple Fugl-Meyer (FMA) score. Results After treatment, the spasticity and motor function of both groups were significantly improved compared with those before treatment, in which MAS score and FMA score of upper limbs and lower limbs in treatment group were superior to those of control group, the difference was statistically significant (P <0.05). The total effective rate of spasm in treatment group was 75.8℅ in upper limbs and 75.8℅ in lower limbs, which were superior to 51.6℅ and 51.6℅ in control group respectively, there was significant difference between the two groups (P <0.05 ). Conclusion The treatment group is better than the control group in improving the spasticity of children with double paralysis, and m NGF can significantly improve the spasticity of upper and lower limbs in children with double paralysis.