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目的:观察乌司他丁在急性胰腺炎临床治疗中的作用效果,分析其临床治疗价值。方法:选取我院治疗的急性胰腺炎患者178例,根据治疗方法不同分为观察组和对照组,每组89例。对照组患者采用奥曲肽治疗,观察组患者采用乌司他丁与奥曲肽联合治疗。观察并比较治疗前后患者APACHEⅡ评分和血清炎症因子变化及临床疗效。结果:入院时,两组血清CRP、IL-1、IL-6、TNF-α、APACHEⅡ评分无统计差异(P>0.05),治疗后,组内CRP、IL-1、IL-6、TNF-α、APACHEⅡ评分明显下降(P<0.05);观察组CRP、IL-1、IL-6、TNF-α、APACHEⅡ评分显著低于参照组(P<0.05);观察组临床总有效率(86.52%)显著高于参照组(71.91%),观察组并发症(12.36%)明显低于参照组(24.72%),P<0.05,组间有统计差异。结论:乌司他丁能够显著提升急性胰腺炎的临床疗效,促进患者康复,其作用机制可能与抑制炎症因子表达有关。
Objective: To observe the effect of ulinastatin in the clinical treatment of acute pancreatitis and analyze its clinical value. Methods: 178 cases of acute pancreatitis treated in our hospital were selected and divided into observation group and control group according to different treatment methods, with 89 cases in each group. The patients in the control group were treated with octreotide, and the patients in the observation group were treated with ulinastatin and octreotide. The changes of APACHEⅡscore and serum inflammatory factors before and after treatment and the clinical curative effect were observed and compared. Results: There was no significant difference in the serum levels of CRP, IL-1, IL-6, TNF-α and APACHEⅡ between the two groups after admission (P> 0.05) (P <0.05). The scores of CRP, IL-1, IL-6, TNF-α and APACHEⅡ in the observation group were significantly lower than those in the reference group (P0.05). The total effective rate in the observation group was 86.52% ) Was significantly higher than that of the reference group (71.91%). The complication of the observation group (12.36%) was significantly lower than that of the reference group (24.72%), P <0.05. Conclusion: Ulinastatin can significantly improve the clinical efficacy of acute pancreatitis and promote the rehabilitation of patients, the mechanism may be related to the inhibition of inflammatory cytokines expression.