京尼平(Genipin)是具有环烯醚萜结构的化合物,具有抗血栓、降血糖、抗肿瘤、抗炎和抗老年痴呆等多种药理活性。近年来,人们通过对其结构进行修饰改造,获得了一系列具有抗阿尔兹海默病(AD)活性的京尼平衍生物。对京尼平及其衍生物抗阿尔兹海默病作用的研究进展进行综述,为京尼平的开发利用提供依据。 Genipin is a compound having an iridoid structure and has various pharmacological activities such as anti-thrombosis, hypoglycemic, anti-tumor, anti-inflammatory and anti-senile dementia. In recent years, people have obtained a series of genipin derivatives with anti-Alzheimer’s disease (AD) activity by modifying their structures. This review summarizes the research progress on the anti-Alzheimer’s disease effect of genipin and its derivatives and provides the basis for the development and utilization of genipin.