曾经指出,各种来源于细菌、牛血清蛋白、蛋白、羊红血球或马血清蛋白的抗原均可通过根管使宿主产生免疫致敏。Nishida等证明兔的牙髓组织,在甲醛中孵化,可获得抗原性并产生特殊的体液反应。Spector氏等曾证明肉芽肿之能永久存在是依靠沉积于巨噬细胞原浆中的刺激原。此外,Rosengren的研究指出,当细菌被限于根管内时,其抗体反应很小,而当感染扩展至根尖周组 It has been pointed out that various antigens derived from bacteria, bovine serum albumin, protein, sheep erythrocytes, or horse serum albumin are immunologically sensitized by the root canal. Nishida et al demonstrated that rabbit pulp tissue, hatched in formaldehyde, gained antigenicity and developed a specific humoral response. Spector et al. Have demonstrated that the persistence of granulomas depends on the stimuli that are deposited in the macrophage plasma. In addition, Rosengren's study pointed out that when the bacteria are confined to the root canal, the antibody response is small, and when the infection spread to the periapical group