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目的:对蛇毒神经生长因子(Nerve growth factor,NGF)凝胶进行了动物实验研究,包括药理学实验,急性毒性实验,皮肤刺激实验和皮肤过敏实验。方法:利用Hartely豚鼠2,4-二硝基氟苯致红斑性皮炎动物模型。结果:NGF凝胶对红斑性皮炎有明显的作用(P<0.01),超过临床1 200倍有效剂量在用药后7天内不能导致皮肤刺激效应和毒性作用。结论:NGF凝胶在治疗皮炎中有显著疗效,无导致全身和局部的不良反应。
OBJECTIVE: To study the animal experiment of snake venom Nerve growth factor (NGF) gel, including pharmacological experiment, acute toxicity test, skin irritation test and skin allergy test. METHODS: An animal model of erythematous dermatitis caused by Hartely guinea pig 2,4-dinitrofluorobenzene was used. RESULTS: The NGF gel had a significant effect on erythematous dermatitis (P<0.01). It exceeded the clinical 1,200-fold effective dose and did not cause skin irritation and toxicity within 7 days after administration. Conclusion: NGF gel has a significant effect in the treatment of dermatitis without causing systemic and local adverse reactions.