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染色体高频率畸变与易导致癌症发生之间的关系曾经被确认,即所谓染色体不稳定性综合征,如毛细血管扩张性共济失调症,范可尼贫血及Bloom氏综合征等。其他疾病中也存在有染色体不稳定性,但频率较低,如HSu等(1981)发现在多发性内分泌肿瘤中有较高程度的染色体畸变。脑脊髓运动失调和系统硬化症、视网膜母细胞瘤、肾脏肿瘤、家族性多发性结肠息肉、皮肤癌、原发性肿瘤、子宫颈癌或癌前期以及遗传性肛门、直肠腺瘤病等病也有类似的染色体不稳定性。
The relationship between high-frequency chromosomal aberrations and predisposition to cancer has been identified as so-called chromosomal instability syndromes such as telangiectasia ataxia, Fanconi anemia and Bloom syndrome. Chromosomal instability also exists in other diseases, but at a lower frequency, such as HSu et al. (1981) found a higher degree of chromosomal aberrations in multiple endocrine tumors. Cerebral spinal motor disorders and systemic sclerosis, retinoblastoma, renal tumors, familial multiple colon polyps, skin cancer, primary tumors, cervical cancer or precancerous and hereditary anal, rectal adenomatosis and other diseases also have Similar chromosomal instability.