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抗癫痫药物是引起皮肤严重不良反应的最常见药物之一,以前研究提示与免疫机制有关,近来药物遗传学研究发现携带HLA-B*1502等位基因的患者在服用卡马西平时可能出现致命的皮肤不良反应,这一特殊基因主要在于亚裔人群中,存在人种差异。在汉族人群中HLA基因型可能能预测抗癫痫药物诱发皮肤严重不良反应的发生,但尚需进一步深入研究。
Antiepileptic drugs are one of the most common drugs that cause serious skin adverse reactions. Previous research suggests that it is related to the immune mechanism. Recent studies in pharmacogenetics have found that patients with HLA-B * 1502 alleles may be fatal when taking carbamazepine Of the skin adverse reactions, this particular gene mainly lies in the Asian population, there are ethnic differences. HLA genotypes in the Han population may predict the occurrence of serious adverse skin reactions induced by antiepileptic drugs, but further study is needed.