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目的:探讨不同时间阴道后穹窿放置米索前列醇对宫颈扩张的效果。方法:选择停经40～60天,自愿选用负压吸引术终止妊振的健康妇女,不给药组(对照组)100例,给药组又分为Ⅰ、Ⅱ、Ⅲ组,每组100例,给药Ⅰ、Ⅱ、Ⅲ组分别于术前1 h、2 h、3 h阴道后穹窿放置米索前列醇0.2 mg。观察用药后不良反应、宫颈扩张度、术中出血量。结果:①各组临床特征比较无统计学差异(P>0.05);②有效宫颈扩张度比较,用药Ⅰ、Ⅱ、Ⅲ组之间差异无统计学意义(P>0.05),但与对照组比较有统计学差异(P<0.05),有良好的可比性;③各组服药后不良反应发生率无统计学差异(P>0.05),Ⅰ、Ⅱ、Ⅲ组术中阴道出血量明显少于对照组。结论:人工流产术前1～3 h阴道后穹窿应用米索前列醇均可使宫颈口扩张效果增强,并可有效避免口服米索前列醇产生的恶心、呕吐、腹泻及术前少量阴道出血等不良反应。
Objective: To investigate the effects of misoprostol on cervical dilatation after vaginal posterior fornix. Methods: 100 healthy women who volunteered to use negative pressure suction to terminate pregnancy-induced vibration for 40 to 60 days were enrolled in this study. The patients in treatment group were divided into Ⅰ, Ⅱ and Ⅲ groups, 100 cases in each group Administration of misoprostol 0.2 mg in vaginal fornix 1 h, 2 h, 3 h before operation, respectively. Adverse reactions observed after treatment, cervical dilation, intraoperative blood loss. Results: ① There was no significant difference in the clinical features among the groups (P> 0.05); ② There was no significant difference in the effective cervical dilatation between groups Ⅰ, Ⅱ and Ⅲ (P> 0.05), but compared with the control group (P <0.05), there is a good comparability; ③ the incidence of adverse reactions in each group after taking no significant difference (P> 0.05), Ⅰ, Ⅱ, Ⅲ intraoperative vaginal bleeding was significantly less than the control group. Conclusion: The application of misoprostol to the vaginal fornix for 1 ~ 3 h before induced abortion can enhance the cervical dilatation effect and effectively prevent the nausea, vomiting, diarrhea and preoperative vaginal bleeding caused by oral administration of misoprostol Adverse reactions.