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轻度交联的聚甲基丙烯酸2-羟乙酯(HEMA)是众所周知的医用水凝胶,即所谓的“Hvdron”。但其吸水率一般在59%(EWC为37%),并不尽人意。近年来,为了提高这类水凝胶的亲水性及生物相容性,常用一些亲水性的烯类单体进行表面改性或通过共聚以达到此目的,N-乙烯基吡咯烷酮是较为常用的这类单体之一。本文合成了含吡咯烷酮基丙烯酸酯类的单体,即丙烯酸2-N-吡咯烷酮基乙酯(PyEA),甲基丙烯酸2-N-吡咯烷酮基乙醋(PyEMA),并研究了这两种单体在甲基丙烯酸二甲氨乙酯(DMAEMA)与过硫酸钾(KPS)所组成的氧化还原引发体系下的聚合。
Mildly cross-linked 2-hydroxyethylmethacrylate (HEMA) is a well known medical hydrogel called the “Hvdron.” However, its water absorption rate is generally 59% (EWC 37%), and unsatisfactory. In recent years, in order to improve the hydrophilicity and biocompatibility of such hydrogels, some hydrophilic vinyl monomers are usually surface-modified or copolymerized to achieve the purpose. N-vinylpyrrolidone is more commonly used One of such monomers. In this paper, pyrrolidone-based acrylate monomers, namely 2-N-pyrrolidonylethyl acrylate (PyEA) and 2-N-pyrrolidone ethyl acetate (PyEMA), were synthesized. Polymerization under a redox initiator system consisting of dimethylaminoethylmethacrylate (DMAEMA) and potassium persulfate (KPS).