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最近研究表明,溴化异丙托品雾化液(IBNS)的防腐剂可致20％以上稳定性哮喘患者发生反常的支气管收缩反应,但用于急性哮喘时的发生率不明。研究旨在确定稳定性与急性哮喘患者用常规剂量含或不含防腐剂的IBNS的急性反应,由于含防腐剂的IBNS为酸性(pH 3.6),故亦检查了pH 7.0不含防腐剂IBNS的反应。对象和方法受试者为稳定性与急性哮喘各25例,均于研究前1个月内有可逆性气道阻塞,且符合美国胸科学会的哮喘诊断标准,组胺激发试验阳性。
Recent studies have shown that IBNS antiseptics can cause an abnormal bronchoconstrictor response in more than 20% of stable asthmatic patients, but the incidence is not known for acute asthma. The aim of the study was to determine the acute and acute response of patients with acute or asthmatic asthma to conventional doses of IBNS with or without preservatives. Since preservative-containing IBNS is acidic (pH 3.6), the pH 7.0 preservative-free IBNS reaction. Subjects and Methods Subjects were stable and acute asthma in each of 25 cases, both within 1 month before the study had reversible airway obstruction, and in line with the American Thoracic Society of asthma diagnostic criteria, histamine challenge test was positive.